Grade 'A' eggs shall be graded by weight as follows:

Grade 3 (interfering with activities of daily living)

Grade 3 or 4 non-hematologic medicine related toxicity

Grade 1 sugar shall have the following characteristics:

Grade 3 hyperbilirubinemia occurred in 1 % of patients.

Grade 3 (painful erythema, edema, or ulcers, but cannot eat)

Grade 3 stomatitis was reported in 2 % of patients in the combination therapy group. No grade 4 stomatitis was reported.

Grade 3 or 4 increases of CPK were observed in 4 % of patients.

Grade 'A' eggs shall have the following minimum characteristics:

Grade 'B' eggs shall have the following minimum characteristics:

Grade 4 sugar shall include sugar not included in Grades 1 to 3.

Grade 3 elevated transaminases were reported in 24 % of patients.

Grade 3 and 4 neutropenia was seen in 7.5 % and 2.7 % of patients, respectively, and grade 3 thrombocytopenia in 0.7 % of patients.

Grade 3-4 mucositis was reported in less than 1 % of the patients.

Grade 3 and 4 Adverse Events MVAC versus Gemcitabine plus cisplatin

Grade 3 or Grade 4 thrombocyte abnormalities, including thrombocytopenic events were observed in 14 % of the patients who received TMZ.

Grade A eggs and "washed eggs" shall be graded by weight as follows:

Graded Approach

A member of temporary staff who has been at one step in his grade for two years shall automatically advance to the next step in that grade.

Grade A eggs and «washed eggs» shall be graded by weight as follows:

A member of the contract staff who has been at one step in his grade for two years shall automatically advance to the next step in that grade.

Grade 3 and 4 anaemia occurred in 10 % and 3 % of patients respectively.

Grade 3 and 4 Adverse Events Paclitaxel versus gemcitabine plus paclitaxel

Grade 2 (interfering with function but not with activities of daily living)

Grade 3-4 fatigue/ asthenia occurred in 9 and 1 % of patients respectively.

A member of temporary staff may be called upon to occupy temporarily a post in a grade in his function group which is higher than his substantive grade.

Within their grade, such contract staff shall be recruited in the first step.

Grade 3 or 4 infusion reactions are uncommon after the first week of therapy.

A member of temporary staff shall be recruited at the first step in his grade.

Grade 3 and 4 neutropenia occurred in 26 % and 24 % of patients respectively).

Grade 3-4 diarrhoea and constipation were reported in less than 1 % of patients.

Grade 3 and 4 thrombocytopenia occurred in 11 % and 2 % of patients respectively.

Grade 3 elevations of AST and ALT occurred in 12 % and 20 % of cycles respectively.

Grade 4 proteinuria (nephrotic syndrome) was seen in up to 1.4 % of treated patients.

Grade 4 neutropenia (< 0.5 x 109/ l) occurred in 9 % of patients treated with Abraxane.

Grade 3-4 nausea and vomiting were reported in 6 % and 6.5 % of patients, respectively.

Gradual Application

Grade 'a' eggs shall not be washed or cleaned by any other means before or after grading.

The grade and step at which temporary staff are engaged shall be stated in their contract.

the contributions shall be calculated by reference to the basic salary for his grade and step.

However, members of the temporary staff in grades AD 9 to AD 13 carrying out the duties of head of unit who are appointed to a higher grade shall be placed in the second step of the new grade.

Grade 3-4 dyspnoea reported as trabectedin related occurred in 2 % of the patients. Alopecia: Alopecia was reported in approximately 3 % of all patients, of which the majority was grade 1 alopecia.

It shall be effected by classifying such contract staff in the first step of the next higher grade.

Grade 3 and 4 Adverse Events Carboplatin versus Gemcitabine plus carboplatin Number (%) of Patients

Where a member of the temporary staff is assigned to a post corresponding to a higher grade, as provided for in the second paragraph of Article 9, he shall be placed in the initial step in that grade.

Grade 2-4 creatine kinase laboratory abnormalities were observed in subjects treated with ISENTRESS.

Grade 'C' eggs shall be eggs which do not meet the requirements applicable to eggs in Grades 'A' and 'B'.

Grade 'A' or 'B' eggs which no longer have the characteristics of those grades but have not been regraded;

Grade 2 or 3 peripheral neurotoxicity was observed more commonly with cisplatin/ paclitaxel (29 % vs. 6 %).

Grade 'B' eggs which have been refrigerated in premises artificially maintained at a temperature below +5 °C;