(1) LD50 oral in rats

(1) LD50 oral in rats.

(2) LD50 dermal in rats or rabbits

(2) LD50 dermal in rats or rabbits.

LD50 value for the sex subjected to a full study, determined at 14 days with the method of determination specified;

LD50 value for the sex subjected to a full study determined at 14 days (with the method of determination specified),

LD50 (median lethal dose) is a statistically derived single dose of a substance that can be expected to cause death in 50 % of dosed animals.

The toxicity/exposure ratios are defined as respectively the quotient of LD50, LC50 or non-observable effects of concentration (NOEC) expressed on an active substance basis and the estimated exposure expressed in mg/kg body weight.

the ratio between the maximum application rate expressed in grammes of active substance per hectare and the contact and oral LD50 expressed in ug of active substance per bee (hazard quotients) and where necessary the persistence of residues on or, where relevant, in the treated plants;

the acute and short-term toxicity/exposure ratio for birds and other non-target terrestrial vertebrates is less than 10 on the basis of LD50 or the long-term toxicity/exposure ratio is less than 5, unless it is clearly established through an appropriate risk assessment that under field conditions no unacceptable impact occurs after use of the plant protection product according to the proposed conditions of use;

100 LD50 units

200 < LD50 <= 2000 mg/kg,

400 < LD50 <= 2000 mg/kg.

QHO = dose/oral LD50 (ig a.s. per bee)

Strength Not less than 1000 LD50 units

QHC = dose/contact LD50 (ig a.s. per bee)

The LD50 may be determined by a recognized method.

The LD50 should be determined by a recognized method.

95 % confidence interval for the LD50 (where this can be provided),

95 % confidence interval for the LD50 (where this can be provided);

TERa = LD50 (mg a.s./kg body weight) / ETE (mg a.s./kg body weight)

The test should provide the LD50 values (by oral and contact exposure).

R 22 Harmful if swallowed Acute toxicity results: - LD50 per oral, rat:

One LD50 unit corresponds to the median lethal dose (LD50) when the reconstituted product is injected intraperitoneally into mice under defined conditions.

The test should provide the acute oral and contact LD50 value of the active substance.

R 21 Harmful in contact with skin Acute toxicity results: - LD50 dermal, rat or rabbit:

Xeomin 100 LD50 units powder for solution for injection [ See Annex I - To be completed nationally ]

Cladribine is moderately acutely toxic to mice, with an LD50 of 150 mg/ kg by intraperitoneal administration.

1 vial contains 100 LD50 units of Clostridium Botulinum neurotoxin type A (150kD), free of complexing proteins

The oral LD50 is approximately 300 mg zinc/ kg body weight (about 100 to 150 times the human therapeutic dose).

1 vial contains 100 LD50 units* of Clostridium Botulinum neurotoxin type A (150 kD), free of complexing proteins.

The LD50 value is expressed in terms of weight of test substance per unit weight of test animal (milligrams per kilogram)

The LD50 value is expressed in terms of weight of test substance per unit weight of test animal (milligrams per kilogram).

When at a dose of 2 000 mg/kg body weight, one animal per sex dies, the LD50 value is expected to exceed 2 000 mg/kg body weight.

The data should be sufficient to produce a dose/response curve and, where possible, permit an acceptable determination of the LD50.