Factors which have to be taken into account in order to establish a "well established medicinal use" of components of medicinal products are the time over which a substance has been used, quantitative aspects of the use of the substance, the degree of scientific interest in the use of the substance (reflected in the published scientific literature) and the coherence of scientific assessments.
Dejavniki, ki jih je treba upoštevati, da bi ugotovili "dobro uveljavljeno medicinsko uporabo" sestavin zdravil so čas uporabe snovi, količinski vidiki uporabe snovi, stopnja znanstvenega zanimanja za uporabo snovi (kar se odraža v objavljeni znanstveni literaturi) in skladnost znanstvenih ocen.