Some indications for its use as a drug and appropriate dosis regimens are presented.

Based on some experimental results, toxicity could be lowered in once-daily dosing regimen as well Clinical experiences bave confirmed experimental results and showed that once-daily dosing of aminoglycosides is at least equally effective and toxic as the conventional multiple dosing regimen in many indications.

Procedures before transplantation (conditioning regimen including total body irradiation and high dose chemotherapy, central line insertion etc.), stem cell collection and transplantation as well as particularity of nursing care are described.

Such studies are especially useful to assist the clinician in establishing dosage regimens (route and site of administration, dose, dosing interval, number of administrations, etc.) and to adopt dosage regimens according to certain population variables (e. g. age, disease).

use of these parameters to investigate the relationships between dosage regimen, plasma and tissue concentration and pharmacologic, therapeutic or toxic effects.

Clinically significant features including the implication of the kinetic data for the dosage regimen especially for patients at risk, and differences between man and animal species used in the pre clinical studies, shall be described.

Dosage regimen

Loading Dose Regimen

Initial Dosing Regimen

Ritonavir Dosing Regimen

Two dosing regimens can be recommended:

This dosage regimen should 12.5 mg/ day

Continue with the prescribed dosage regimen.

The following dosing regimen should be used:

The prescribed dosage regimen should be continued.

Other dose regimens should be scientifically justified.

Therefore no special dosage regimen can be recommended.

The following dosage regimens are given as a guideline.

The following dosage regimens are given as a guideline:

In one of the studies, two dose regimens were examined:

Dosing regimens in Phase II and Phase III studies Phase

This dosage regimen should be used when the following are

Monitoring and modification of the Refludan dosage regimen

The dose and dosage regimen is dependent on the indication.

The dose and dosage regimen are dependent on the indication.

The following weight-adjusted dosing regimens are recommended

The recommended dosing regimen is presented in Tables 1 and 2.

The following weight-adjusted dosing regimens are recommended:

use of a five-day per week dosing regime needs to be justified.

Alternative dosing regimens have been used in clinical studies.

Note: ritonavir was dosed after a meal for all listed regimens.

This dosage regimen should be used when the following are added

The recommended dose does not depend on the anaesthetic regimen.

In clinical trials the dosage regimen in table 1 below was used:

* Total daily dose (mg/day) should be divided as indicated by dose regimen to provide mg/dose + Supplementary dose is a single additional dose

5 In a phase 4 study 33 MPS1 patients received 1 of 4 dose regimens:

Response was similar in both dosing regimens and across patient age.

Posology The dose and dosage regimen is dependent on the indication.

Dosing regimen adjustment of Sebivo in patients with renal impairment

Also, both dosing regimens were effective in reducing the viral load.

Dosage regimen in renal impairment, in dialysis patients and elderly:

The dose may vary depending upon the immunosuppressive regimen chosen.

The following dosing regimen was used in study AC-052-356 (BREATHE-3):

In both studies, all patients received a 16/ 16 dose regimen of Busilvex.

All three doses must be administered to complete the vaccination regimen.

Specific studies for the 3-monthly dosing regimen have not been performed.