A total of 697 patients were randomized in a 2:1 ratio to either irbesartan/ hydrochlorothiazide 150 mg/ 12.5 mg or to irbesartan 150 mg and systematically force- titrated (before assessing the response to the lower dose) after one week to irbesartan/ hydrochlorothiazide 300 mg/ 25 mg or irbesartan 300 mg, respectively.
Skupaj je bilo randomiziranih 697 bolnikov v razmerju 2: 1, bodisi na irbesartan/ hidroklorotiazid 150 mg/ 12, 5 mg bodisi na irbesartan 150 mg. Po enem tednu zdravljenja so odmerek sistematično povečali (pred ovrednotenjem odziva na nižji odmerek) na irbesartan/ hidroklorotiazid 300 mg/ 25 mg oziroma irbesartan 300 mg.