Experimental animal studies are insufficient to assess the safety with respect to reproduction, development of the embryo or foetus, the course of gestation and peri- and postnatal development.

Experimental animal studies are insufficient to assess the safety with respect to reproduction, development of the embryo or foetus, the course of gestation and peri- and post-natal development.

The experimental animals died due to the cardio-respiratory arrest.

These diseases are transmissible to experimental animals by inoculation or by ingestion in food.

EUROPEAN CONVENTION FOR THE PROTECTION OF VERTEBRATE ANIMALS USED FOR EXPERIMENTAL AND OTHER SCIENTIFIC PURPOSES

A single application, injections twice weekly for a total of ten or throughout the survival of the experimental animals were used.

Different rating scales and behavioural responses have proposed as a measaure in different animal species for each experimental model.

After experimental periodontal breakdown followed in 15 beagle dogs, all the teeth were scaled supragingivally and animals were divided into three groups.

Equinatoxin l induces acute necrosis of myocardium. Together with pulmonary edema this is the most important mechanism that leads to the death of experimental animals.

Following the early attempts to produce parkinsonian signs and symptoms by means of discrete brain lesions, reserpine provided the first experimental model of parkinsonism in animals.

This Convention applies to any animal used or intended for use in any experimental or other scientific procedure where that procedure may cause pain, suffering, distress or lasting harm.

Recalling that the aim of the Council of Europe is to achieve a greater unity between its members and that it wishes to co operate with other States in the protection of live animals used for experimental and other scientific purposes;

Recalling that the aim of the Council of Europe is to achieve a greater unity between its members and that it wishes to co-operate with other States in the protection of live animals used for experimental and other scientific purposes;

Resolved to limit the use of animals for experimental and other scientific purposes, with the aim of replacing such use wherever practical, in particular by seeking alternative measures and encouraging the use of these alternative measures;

c. ` procedure` means any experimental or other scientific use of an animal which may cause it pain, suffering, distress or lasting harm, including any course of action intended to, or liable to, result in the birth of an animal in any such conditions, but excluding the least painful methods accepted in modern practice (that is ` humane` methods) of killing or marking an animal.

Advisory Committee on the Protection of Animals Used for Experimental and Other Scientific Purposes:

TO REFRAIN FROM APPLYING THE PROVISIONS OF THIS DIRECTIVE TO COMPOUND FEEDINGSTUFFS WHERE A SPECIAL LABEL MARKING GIVES PROOF THAT THEY ARE INTENDED FOR ANIMALS KEPT FOR SCIENTIFIC OR EXPERIMENTAL PURPOSES.

"birds" mean: animals of avian species not covered by Article 2 number 1 of Council Directive 90/539/EEC(6) excluding birds referred to in Article 1 third paragraph (relating to pet birds accompanying their owner) and Article 19 of Directive 92/65/EEC (relating to birds for zoos, circuses, amusement parks and experimental laboratories),

Directive 2004/9/EC of the European Parliament and of the Council of 11 February 2004 on the inspection and verification of good laboratory practice (GLP) (codified version)(22); and Council Directive 86/609/EEC of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes(23).

Bio-safety requirements for experimental animal rooms

Experimental Animals

Experimental animals

experimental or laboratory animals;

The environmental conditions in the experimental animal rooms or enclosures should be appropriate to the test species.

Both eyes of each experimental animal provisionally selected for testing should be examined within 24 hours before testing starts.

In the case of substances or medicinal products intended solely for use in non food-producing animals, a repeated dose toxicity study in one species of experimental animal will normally be sufficient.

- number of animals of each sex in experimental and control groups;

- number of animals for each sex in experimental and control groups;