The failure to reduce the burden of these diseases and the evidence of their increasing impact have brought them to the centre of the development debate - as evidenced by the Declaration of Commitment of the Special Session of the UN General Assembly of June 2001, which recognises that HIV/AIDS has evolved to become a developmental emergency, and by the WHO World Health Assembly's declaration of tuberculosis and malaria as global emergencies - and have led to calls for urgent action and a series of national, regional and international initiatives, all meant to achieve the Millennium Development Goals which include clear targets to fight HIV/AIDS, tuberculosis and malaria, and to which the European Community and its Member States committed themselves.
Neuspeh, da bi zmanjšali breme teh bolezni, in njihov dokazano naraščajoč vpliv so jih postavili v središče razvojnih razprav - kot dokazujeta Deklaracija zavez, sprejeta na posebnem zasedanju Generalne skupščine ZN junija 2001, ki priznava, da HIV/AIDS predstavlja izredno stanje, ki grozi razvoju, in razglasitev tuberkuloze in malarije za globalno izredno stisko na zasedanju Svetovne zdravstvene skupščine WHO - in vodili k zahtevam po nujnih ukrepih in vrsti nacionalnih, regionalnih in mednarodnih pobud, namenjenih doseganju Razvojnih ciljev tisočletja, ki zajemajo jasne cilje za boj proti HIV/AIDSU, tuberkulozi in malariji, k izpolnjevanju katerih se je zavezala Evropska skupnost in njene države članice.