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hypoxanthine-guanine phosphoribosyl transferase
1 Prevajalska redakcija
izobraževanje
CELEX: 32000L0032
In these cell lines the most commonly used genetic endpoints measure mutation at thymidine kinase (TK) and hypoxanthine-guanine phosphoribosyl transferase (HPRT), and a transgene of xanthine-guanine phosphoribosyl transferase (XPRT).
V teh celičnih linijah najpogosteje uporabljane genske končne točke izmerijo mutacijo na lokusih za timidin-kinazo (TK) in hipoksantin-gvanin-fosforibozil-transferazo (HPRT) in na transgenu za ksantin-gvanin-fosforibozil-transferazo (XPRT).
2 Prevajalska redakcija
RS
EMEA
On theoretical grounds, therefore, it should be avoided in patients with rare hereditary deficiency of hypoxanthine-guanine phosphoribosyl-transferase (HGPRT) such as Lesch-Nyhan and Kelley-Seegmiller syndrome.
Na podlagi teoretičnih osnov zdravila Myfenax ne dajemo bolnikom z redkim dednim pomanjkanjem hipoksantin- gvanin- fosforibozil - transferaze (HGPRT), kot sta Lesch- Nyhlanov in Kelley- Seegmillerjev sindrom.
3 Prevajalska redakcija
RS
EMEA
Paclitaxel has been shown to be genotoxic in vivo (micronucleus test in mice), but it did not induce mutagenicity in the Ames test or the Chinese hamster ovary/ hypoxanthine-guanine phosphoribosyl transferase (CHO/ HGPRT) gene mutation assay.
Paklitaksel ima in vivo genotoksične učinke (mikronukleusni test pri miših), čeprav pri Amesovem testu ali analizi genskih mutacij z uporabo jajčnika kitajskega hrčka brez gena za hipoksantin- gvanin - fosforibozil- transferazo (CHO/ HGPRT) ni induciral mutagenosti.
4 Prevajalska redakcija
izobraževanje
CELEX: 32000L0032
N., Hsie, A. W., Gupta, R. S., Loveday, K. S., ÓNeill, J. P., Riddle, J. C., Stankowski, L. F. Jr. and Yang, L. L. (1987), A Guide for the Performance of the Chinese Hamster Ovary Cell/Hypoxanthine-Guanine Phosphoribosyl Transferase Gene Mutation Assay, Mutation Res., 189, pp. 135-141.
N., Hsie, A. W., Gupta, R. S., Loveday, K. S., ÓNeill, J. P., Riddle, J. C., Stankowski, L. F. Jr., in Yang, L. L. (1987), A Guide for the Performance of the Chinese Hamster Ovary Cell/Hypoxanthine-Guanine Phosphoribosyl Transferase Gene Mutation Assay, Mutation Res., 189, str. 135-141.
Prevodi: en > sl
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hypoxanthine-guanine phosphoribosyl transferase