In the case of new combinations of known substances which have been investigated in accordance with the provisions of this Directive, the repeated-dose tests may, except where toxicity tests have demonstrated potentiation or novel toxic effects, be suitably modified by the investigator, who shall submit his reasons for such modifications.
V primeru novih kombinacij znanih snovi, ki so bile raziskane v skladu z določili te direktive, lahko raziskovalec preskuse pri ponovljenih odmerkih, razen če so preskusi toksičnosti izkazali potenciranje novih toksičnih učinkov, primerno prilagodi, mora pa navesti razloge za prilagoditve.