Different rating scales and behavioural responses have proposed as a measaure in different animal species for each experimental model.

The arithmetic average of the ten years shall be weighted on a decreasing linear scale, so that the ratio of the relevant year shall have a weight of 10, the year prior to the relevant year shall have a weight of 9, the next preceding year shall have a weight of 8, and so on, until the tenth year has a weight of 1.

(2) The initial contribution shall be 5% of an amount calculated by applying the percentage obtained for the State in question, on the date on which ratification or accession takes effect, in accordance with the scale provided for in Article 40, paragraphs 3 and 4, to the sum of the special financial contributions due from the other Contracting States in respect of the accounting periods preceding the date referred to above.

Wide restructuring, through mergers and joint ventures, is taking place in order to compete more effectively on the deregulated market through economies of scale and rationalization.

They may enable the companies to rationalize and to reach the critical mass necessary to obtain the economies of scale needed to make the important investments in research and development.

Patients' self-reports of symptoms using the Edmonton Symptom Assessment Scale (ESAS), and ratings of pain or discomfort associated with ICU diagnostic/therapeutic procedures and of stress associated with conditions in the ICU.

The basic salary taken into account for determining the recipient's pension shall be equivalent to the salary in the table in Article 66 of the Staff Regulations for the new grade thus determined, at the same step, weighted by a percentage equivalent to the ratio of basic salary under the old scale to that under the scale in Article 66 of the Staff Regulations for the same step.

"Scale factor" (gyro or accelerometer) (7) means the ratio of change in output to a change in the input intended to be measured.

The basic salary taken into account for determining the recipient's pension shall be equivalent to the salary in the table in Article 66 of the Staff Regulations for the new grade thus determined, at the same step, weighted by a percentage equivalent to the ratio of basic salary under the old scale to that under the scale in Article 66 of the Staff Regulations for the same step.

In case of a change in the head space or a change in the surface/volume ratio, stability studies in accordance with the relevant guidelines have been started with at least two pilot scale (three for biological medicinal products) or industrial scale batches and at least three months' (six months for biological medicinal products) stability data are at the disposal of the applicant.

It is desirable to ensure the continuity of the activities supported by the framework programme, by providing for their coordination within a single frame of reference that rationalises procedures and improves management and economies of scale.

The Parties shall encourage the conferring of a regional character on any aspect of cooperation which, by virtue of its scope or economies of scale, results in what they consider to be a more rational and efficient use of available resources and a better outcome.

In addition, the modernization or conversion work on existing fishing vessels referred to in Article 2 (a) must be carried out on a large scale for the purpose of rationalizing fishing operations, better preserving catches or saving energy and total a minimum of 65 000 ECU per project.

type of material and approximate number of items to be supplied, - value rating according to the scale given in Annex 2, - whether buyers and any guarantors are public or private, - if transaction is to be put for international tender, closing date for submission of tenders; (d) principal credit terms applied for by proposed recipient; (e) credit terms the authorities in the exporting country propose to offer:

The scale of contributions to be paid by the Member States referred to in Article 21, on the one hand, and by Iceland and Norway ('the other States'), on the other hand, shall be calculated annually on the basis of the share of each Member State concerned and of the other States in the total gross domestic product (GDP) for the preceding year of all the States referred to in Article 21. The scale of contributions by the Member States concerned shall be calculated annually, taking into account the other States' contributions, on the basis of the ratio of the VAT resources paid by each of those Member States to the total VAT resources of the European Communities, as established in the last amendment of the budget of the Communities during the preceding financial year.

value rating according to the scale given in Annex 2,

Each Member State shall divide the ecological quality ratio scale for their monitoring system for each surface water category into five classes ranging from high to bad ecological status, as defined in Section 1.2, by assigning a numerical value to each of the boundaries between the classes.

All patients treated suffered from a major depressive disorder, the severity of which was assessed using a standard rating scale (the Hamilton Rating Scale for Depression, HAM-D).

In all studies, the effectiveness of Zyprexa was assessed using various symptom rating scales.

The main measure of effectiveness was the change in symptoms over 26 weeks, as assessed on a standard scale (Unified Parkinson’ s Disease Rating Scale, UPDRS).

Relief of the symptoms of GAD as reflected by the Hamilton Anxiety Rating Scale (HAM-A) was observed by Week 1.

The effectiveness was measured by looking at the score in the HAM-D rating scale before and at the end of the study.

The main measure of effectiveness in these five studies was the change in symptoms after six weeks, as measured on a standard scale for depression called the Hamilton Depression Rating Scale (HAM-D).

Actual scores in rating scales used as secondary endpoints, including PANSS and the Montgomery-Asberg Depression Rating Scale showed a significant improvement over haloperidol.

(Invented name)® has been shown to be significantly more effective than placebo as measured by the Hamilton Depression Rating Scale (HAM-D).

The studies measured the scores before and after treatment obtained with a standard questionnaire called the Unified Parkinson’ s Disease Rating Scale (UPDRS).

The MAH has defined severe idiopathic RLS as those patients who have an International Restless Legs Syndrome Rating Scale (IRLS) baseline score of 24 points or more.

In this study, the primary measure of efficacy was the change from baseline in the total score of the Unified Parkinson’ s Disease Rating Scale (UPDRS, parts I-III).

28 Secondary end-points included change of pain, global rating of quality of life by EuroQoL-5D, Lung Cancer Symptom Scale, and changes in Karnosfky performance status.

The mean change from baseline in the Restless Legs Syndrome Rating Scale (IRLS) and the Clinical Global Impression-Improvement (CGI-I) were the primary efficacy outcome measures.

Wide restructuring, through mergers and joint ventures, is taking place in order to compete more effectively on the deregulated market through economies of scale and rationalization.

They may enable the companies to rationalize and to reach the critical mass necessary to obtain the economies of scale needed to make the important investments in research and development.

the two producing groups have rationalised their production process and adapted their structures, the third producer's efforts were primarily based on the realisation of economies of scale.

Effectiveness was measured by looking at the change in symptoms (severity, pain and disability) after four weeks, measured using the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS).

The changes from baseline in the International RLS Rating Scale (IRLS) and CGI-item 1 (severity of illness) were primary efficacy parameters. For both primary endpoints statistically significant

In the treatment of generalised anxiety disorder, eight studies involved over 3,000 patients, the effectiveness of Lyrica was measured using an anxiety questionnaire (Hamilton Anxiety Rating Scale).

The primary outcome assessment was the score for the Activities of Daily Living (ADL) component (Part II) plus the Motor Examination component (Part III) of the Unified Parkinson’ s Disease Rating Scale (UPDRS).

In a 6- week, placebo-controlled trial involving titration of risperidone in doses up to 10 mg/ day administered twice daily, risperidone was superior to placebo on the Brief Psychiatric Rating Scale (BPRS) total score.

CYMBALTA demonstrated statistical superiority over placebo as measured by improvement in the 17-item Hamilton Depression Rating Scale (HAM-D) total score (including both the emotional and somatic symptoms of depression).

XERISTAR demonstrated statistical superiority over placebo as measured by improvement in the 17- 11 item Hamilton Depression Rating Scale (HAM-D) total score (including both the emotional and somatic symptoms of depression).

Pharmacokinetic/ pharmacodynamic relationship There was no relationship between the plasma concentrations of the active antipsychotic fraction and the change in total PANSS (Positive And Negative Syndrome Scale) and total ESRS (Extrapyramidal Symptom Rating Scale) scores across the assessment visits in any of the phase-III trials where efficacy and safety was examined.

Skin irritation In clinical trials, skin reactions were measured at each visit using a skin irritation rating scale that rated the degree of erythema, oedema, scaling, fissures, pruritus and pain/ stinging/ burning at the application site.

On enrolment all patients had Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) -Total scores of 20 or greater with at least two muscles involved, no neck contractures or other causes of decreased neck range of motion, and no history of any other neuromuscular disorder.

In a 24-week double-blind study, the most commonly observed symptoms (skin irritation rating scale) with Exelon 9.5 mg/ 24 h transdermal patches were very slight (21.8 %), mild (12.5 %) or moderate (6.5 %) erythema or very slight (11.9 %), mild (7.3 %) or moderate (5.0 %) pruritus.

In a 24-week double-blind study, the most commonly observed symptoms (skin irritation rating scale) with Prometax 9.5 mg/ 24 h transdermal patches were very slight (21.8 %), mild (12.5 %) or moderate (6.5 %) erythema or very slight (11.9 %), mild (7.3 %) or moderate (5.0 %) pruritus.

In a multinational, double-blind, comparative study of schizophrenia, schizoaffective, and related disorders which included 1,481 patients with varying degrees of associated depressive symptoms (baseline mean of 16.6 on the Montgomery-Asberg Depression Rating Scale), a prospective secondary

(Invented name)®, at a dose of 20mg, has been shown to be significantly more effective than placebo in two short-term pivotal studies, as measured by the reduction of Childhood Depression Rating Scale-Revised (CDRS-R) total scores and Clinical Global Impression of Improvement (CGI-I) scores.

The arithmetic average of the 10 years shall be weighted on a decreasing linear scale, so that the ratio of the relevant year shall have a weight of 10, the year prior to the relevant year shall have a weight of nine, the next preceding year shall have a weight of eight, and so on, until the 10th year has a weight of one.

Consortia, as defined in this Regulation, generally help to improve the productivity and quality of available liner shipping services by reason of the rationalisation they bring to the activities of member companies and through the economies of scale they allow in the operation of vessels and utilisation of port facilities.