MFI-MPEC cross-check

Note that inconsistent MFI-MPEC records will not be part of the snapshot.

An MFI-MPEC cross-check provides a warning only.

This message could be sent by one or both of the MFI-MPEC business areas,

MFI and MPEC discrepancies are checked by the respective MFI and MPEC business areas, five working days prior to, and on the day of, the end-month release.

Note that inconsistent MFI-MPEC records will not be published on the ECB's website at the end of each month.

The acknowledgement will contain only the result of the cross-check between the MFI and the MPEC datasets of the sender.

where MFI and MPEC data can be coordinated between respective business areas, the cross-check flag should be included only in the second file transmitted for the corresponding MFI or MPEC request,

The cross-check is carried out on the complete MFI and MPEC information reported by the sender NCB (i.e. including existing MFI and MPEC information in the respective datasets) and not just on the information received in the file containing the flag.

where a cross-check is not required immediately for MFI-MPEC consistency, the flag should not be placed in the file,

If a cross-check of data between the MFI and MPEC datasets is required, place a cross-check flag in the file being transmitted in the N13 Data Exchange System.

Transmission of ad hoc updates of the MFI sector is mandatory, both to ensure full consistency with the eligible counterparties for monetary policy operations (hereinafter "MPEC") and for the monthly release of the list of MFIs on the European Central Bank"s (ECB"s) website.

Pegylated liposomes contain surface-grafted segments of the hydrophilic polymer methoxypolyethylene glycol (MPEG).

mean-photo effect (MPE)

MPE (mean photo effect):

Caelyx, a liposome formulation, is doxorubicin hydrochloride encapsulated in liposomes with surface- bound methoxypolyethylene glycol (MPEG).

These linear MPEG groups extend from the liposome surface creating a protective coating that reduces interactions between the lipid bilayer membrane and the plasma components.

α -(2-[1,2-distearoyl-sn-glycero(3)phosphooxy]ethylcarbamoyl)-ω -methoxypoly(oxyethylen)- 40 sodium salt (MPEG-DSPE) fully hydrogenated soy phosphatidylcholine (HSPC) cholesterol ammonium sulphate sucrose histidine water for injections hydrochloric acid sodium hydroxide

The relative non-toxicity of monomethoxy-polyethylene glycol (mPEG), which is liberated from PegIntron by metabolism in vivo has been demonstrated in preclinical acute and subchronic toxicity studies in rodents and monkeys, standard embryo-foetal development studies and in in vitro mutagenicity assays.

The relative non-toxicity of monomethoxy-polyethylene glycol (mPEG), which is liberated from ViraferonPeg by metabolism in vivo has been demonstrated in preclinical acute and subchronic toxicity studies in rodents and monkeys, standard embryo-foetal development studies and in in vitro mutagenicity assays.

DÉPARTEMENT VALORISATION ET INSPECTION SANITAIRE (MPEM-CNROP-DVIS)`

The pharmacokinetics and metabolism of MPEG5000 DPPE have not been evaluated in humans.

whereas that list must be drawn up on the basis of a communication from the MPEM-CNROP-DVIS to the Commission;

The model uses the 'mean photo effect' (MPE), a measure which is based on comparison of the complete concentration response curves.

whereas it is therefore for the MPEM-CNROP-DVIS to ensure compliance with the provisions laid down to that end in Article 11 (4) of Directive 91/493/EEC;

For application of the MPE model, a special computer software was developed at the Humboldt University (Berlin), which can be obtained free of charge.

A positive result in the in vitro 3T3 NRU phototoxicity test (PIF >= 5 or MPE >= 0,1) indicates that the test substance has phototoxic potential.

Name(s) and official approval number(s) of establishment(s) or freezer vessel(s) approved by the MPEM-CNROP-DVIS for exports to the Community:

Département Valorisation et Inspection Sanitaire (MPEM-CNROP-DVIS)`, the competent authority in Mauritania, is capable of effectively verifying the application of the laws in force;

The certificate must bear the name, capacity and signature of the representative of the 'Ministere des Peches et de l'Économie Maritime - Centre National de Recherches Océanographiques et des Peches - Département Valorisation et Inspection Sanitaire (MPEM-CNROP-DVIS)`, and the latter's official stamp in a colour different from that of the other indications on the certificate.

In the present test guideline, PIF and MPE can be used for transformation of the results of the in vitro 3T3 NRU phototoxicity test into a prediction of phototoxic potential.

In this case, based on historical data, the ranges of EC50 values and PIF or MPE (mean photo effect) should be adequately defined as acceptance criteria for the test.

A negative result from the in vitro 3T3 NRU phototoxicity test (PIF < 5 or MPE < 0,1) indicates that the test substance was not phototoxic to the cultured mammalian cells under the conditions used.

5 or MPE < 0,1) indicates that the test substance was not phototoxic to the cultured mammalian cells under the conditions used.

comparison of the two concentration response curves, obtained in the presence and in the absence of UVA/vis irradiation, either by calculation of the photo irritation factor (PIF), or by calculation of the mean photo effect (MPE),

The naturally occurring phospholipids in Luminity (see section 6.1) are distributed in the endogenous lipid pools in the body (for example, liver) whereas the synthetic component (MPEG5000) has been shown to be excreted in the urine in preclinical studies.

Whereas the MPEM-CNROP-DVIS has provided official assurances regarding compliance with the rules set out in Chapter V of the Annex to Directive 91/493/EEC and regarding fulfilment of requirements equivalent to those laid down by that Directive for the approval of establishments and the freezer vessels;

1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) 1,2-dipalmitoyl-sn-glycero-3-phosphatidic acid, monosodium salt (DPPA) N-(methoxypolyethylene glycol 5000 carbamoyl)-1,2-dipalmitoyl-sn-glycero-3- phosphatidylethanolamine, monosodium salt (MPEG5000 DPPE) Sodium dihydrogen phosphate monohydrate Disodium hydrogen phosphate heptahydrate Sodium chloride Propylene glycol Glycerol Water for injections

1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), 1,2-dipalmitoyl-sn-glycero-3-phosphatidic acid, monosodium salt (DPPA), N-(methoxypolyethylene glycol 5000 carbamoyl)-1,2-dipalmitoyl-sn-glycero-3-phosphatidylethanolamine, monosodium salt (MPEG5000 DPPE), sodium dihydrogen phosphate monohydrate, disodium hydrogen phosphate heptahydrate, sodium chloride, propylene glycol, glycerol, water for injections

Computer controlled, "numerically controlled" or "stored programme controlled" co-ordinate measuring machines (CMM), having a three dimensional (volumetric) maximum permissible error of indication (MPEE) at any point within the operating range of the machine (i.e., within the length of axes) equal to or less (better) than (1,7 + L/1000) µm (L is the measured length in mm), tested according to ISO 10360-2 (2001);

The other ingredients are 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), 1,2-dipalmitoyl- sn-glycero-3-phosphatidic acid, monosodium salt (DPPA), N-(methoxypolyethylene glycol 5000 carbamoyl)-1,2-dipalmitoyl-sn-glycero-3-phosphatidylethanolamine, monosodium salt (MPEG5000 DPPE), sodium dihydrogen phosphate monohydrate, disodium hydrogen phosphate heptahydrate, sodium chloride, propylene glycol, glycerol and water for injections.