V primerih, ko niso na voljo niti absolutne metode definicije ne certificirani referenčni materiali, je mogoče vsebnost analita v vzorcu opredeliti z rezultati, dobljenimi s pomočjo metode, ki izkazuje visoko stopnjo specifičnosti, točnosti in natančnosti.
In cases where neither absolute defining methods nor certified reference materials are available, the analyte content of a sample may be defined by the results obtained with the aid of a method which exhibits a high degreee of specificity, accuracy and precision for the analyte.