Linearity

The linearity shall be within ± 2 % opacity.

The linearity must not differ by more than ± 2 % opacity from the nominal value of the neutral density filter.

The linearity of the opacimeter shall be checked in the opacity readout mode as per the manufacturer's recommendations.

T he linearity of the calibration curve is good for concentrations between 1,00 and 15,00 Δ›g/ml.

T he linearity of the calibration curve is good for concentrations between 1,00 and 15,00 μg/ml.

Ensure that the response is linear by successively analysing in triplicate each of the linearity standard solutions (5.14.6) containing internal standard (IS).

Linearity/ non-linearity:

Linearity / non-linearity Telbivudine pharmacokinetics are dose proportional over the range of 25 to 1,800 mg.

Linearity Amlodipine and valsartan exhibit linear pharmacokinetics.

Linearity of the system must be validated over the concentration ranges of interest.

The linearity of the calibration curve is good for concentrations between 1,00 and 15,00 mg/ml.

Linearity The increase in mean AUC is linear and dose proportional in the therapeutic range.

Linearity Exposure to aliskiren increased slightly more than in proportion to the increase in dose.

Linearity/ non linearity The kinetics of ivabradine is linear over an oral dose range of 0.5 – 24 mg.

Linearity Anidulafungin displays linear pharmacokinetics across a wide range of once daily doses (15-130 mg).

Linearity The pharmacokinetics of risperidone following single doses of RISPERDAL CONSTA are linear in the dose range of 12.5-75 mg.

Linearity is defined as the ability of the method, within a given range, to obtain an acceptable linear correlation between the results and the concentration of analyte in samples.

The linearity of the circuit shall be such that no error greater than p 0,001 oC is introduced at any point within the range -0,400 oC to -0,600 oC when the instrument is correctly operated.

Linearity / non-linearity The Cmax for vildagliptin and the area under the plasma concentrations versus time curves (AUC) increased in an approximately dose proportional manner over the therapeutic dose range.

Linearity / non-linearity The C max for vildagliptin and the area under the plasma concentrations versus time curves (AUC) increased in an approximately dose proportional manner over the therapeutic dose range.

Linearity / non-linearity Steady-state nilotinib exposure was dose-dependent, with less than dose-proportional increases in systemic exposure at dose levels higher than 400 mg given as once-daily dosing.

Dose linearity The systemic exposure of ustekinumab (Cmax and AUC) increased in an approximately dose- proportional manner after a single intravenous administration at doses ranging from 0.09 mg/ kg to 4.5 mg/ kg or following a single subcutaneous administration at doses ranging from approximately 24 mg to 240 mg in patients with psoriasis.

Establishment of the Linearity Response

Any neutral density filter used in conjunction with opacimeter calibration, linearity measurements, or setting span shall have its value known to within 1,0 % opacity.

the specificity and linearity of the proposed methods,

- linearity,

Standard solutions used to check the linearity of response of FID

"Linearity" equal to or less (better) than 0,1% within a measuring range up to 5 mm;

"Linearity" (2) (usually measured in terms of non-linearity) means the maximum deviation of the actual characteristic (average of upscale and downscale readings), positive or negative, from a straight line so positioned as to equalise and minimise the maximum deviations.

Three or more are preferred in the range 0 to 50 °C, in order to check the linearity of the vapour pressure curve.

Linearity:

Accelerometers with a threshold of 0,05 g or less, or a linearity error within 0,25% of full scale output, or both, which are designed for use in inertial navigation systems or in guidance systems;

Linearity/ Non-linearity

Linearity test

Specificity, linearity, accuracy and repeatability

Check of linearity

Linearity/ non-linearity: The bioavailability of rufinamide is dependent on dose.

The linearity of proposed methods over an appropriate range must be determined and reported.

The linearity of proposed methods over an appropriate range, must be determined and reported.

≤ 0.5 ‰ for breath samples varying between 1 % and 7 % CO2- concentration

Such means shall not affect the linearity or the spectral characteristics of the instrument.

For verifying the specifications linearity, stability, and precision of measurement have to be tested.

The principle tests to verify the specifications are linearity, stability (reference gas precision), and precision of measurement.

Linearity/ non-linearity Tadalafil pharmacokinetics in healthy subjects are linear with respect to time and dose.

Linearity/ non-linearity Exposure to aliskiren increased more than in proportion to the increase in dose.

Linearity/ non-linearity The pharmacokinetics of tenofovir were independent of tenofovir disoproxil fumarate dose over the dose range 75 to 600 mg and were not affected by repeated dosing at any dose level.

The principal tests to verify the specifications are linearity, stability (reference gas precision), and precision of measurement.

Analysis of the linearity response test solutions

Prior to the commencement of the analysis the linearity of the response of the FID should be checked by successively analysing in triplicate each of the linearity standard solutions (4.5.3).