In the past patients with non-severe aplastic anemia were used to be treated with androgenic steroids or low-dose glucocorticoids, but recently the therapy has hben replaced by, antilymphocytic globulin and/or cyclosporin.

As the disease progresses, the timing, dose, and formulation of levodopa must be individualized and new dopamine agonists should be introduced, apomorphine being particularly suitable for rapid alleviation of disabling ""offs"".

for each presentation of the product, the pharmaceutical form and content in weight, volume or units of dosage;

The content of active substances, expressed quantitatively per dosage unit, per unit of volume or weight according to the dosage form.

The pharmaceutical form and the contents by weight, volume or number of dose-units need only be shown on the outer package.

dosage for the various species of animal for which the veterinary medicinal product is intended, its pharmaceutical form, method and route of administration and proposed shelf life;

The antigen must also be suitable for the preparation of oil emulsion vaccines for pigs, in which case 1 / 6 of a dose volume must protect at least 5 out of 10 pigs if challenged by intrapodal injection of 1 000 ID50.

In order to give the "quantitative composition" of the active substance(s) of the finished medicinal products, it is necessary, depending on the pharmaceutical form concerned, to specify the mass, or the number of units of biological activity, either per dosage-unit or per unit of mass or volume, of each active substance.

Where a medicinal product is intended for a different therapeutic use or presented in a different pharmaceutical form or to be administered by different routes or in different doses or with a different posology, the results of appropriate toxicological and pharmacological tests and/or of clinical trials shall be provided.

Having regard to the particular characteristics of these homeopathic veterinary medicinal products, such as the very low level of active principles they contain and the difficulty of applying to them the conventional statistical methods relating to clinical trials, it is desirable to provide a special, simplified registration procedure for those traditional homeopathic medicinal products which are placed on the market without therapeutic indications in a pharmaceutical form and dosage which do not present a risk for the animal.

MULTIDOSE (20 DOSES) PRESENTATION

MULTIDOSE PRESENTATION VIAL (10 DOSES) X 50 VIAL (20 DOSES) X 50 AMPOULE (10 DOSES) X 50

Do not use as an intravenous bolus.

Less than 2 % of the dose is excreted in the urine as unchanged irbesartan.

About 20 % of the dose has been accounted for in urine as metabolite.

ZOSTAVAX is given as a single dose by injection.

Most of the dose of cefuroxime is excreted unchanged.

Cetrotide 3 mg is given as a single dose on day 7.

After 24 hours, about 60 % of the dose is excreted unchanged in the urine.

About 9 % of the dose is recovered in the faeces, primarily as metabolites.

About 10 % of the administered dose is eliminated via urine as metabolites.

Guidelines were developed in clinical trials for dose modification.

Less than 5 % of the dose is excreted in urine, mainly as metabolites.

for each presentation of the product, the pharmaceutical form and content in weight, volume or units of dosage;

About 70 % of the dose is excreted in the urine as inactive metabolites.

Less than 5 % of the dose is excreted unchanged in the urine and faeces.

the maximum single dose, the maximum daily dose, the strength, the pharmaceutical form, certain types of packaging;

Less than 2 % of the orally administered dose is excreted as parent substance.

Thirteen percent of the emtricitabine dose was recovered in urine as three metabolites.

Less than 1 % of the dose is excreted as unchanged active ingredient.

Approximately 20 % of a timolol dose is excreted in the urine unchanged and the remainder excreted in urine as metabolites.

This may be administered as either 150 mg twice daily or 300 mg once daily (see section 4.4).

The safety profiles were comparable for the two different formulations after a single dose.

Elimination Urinary excretion of unchanged paroxetine is generally less than 2 % of dose whilst that of metabolites is about 64 % of dose.

Daily dosages of greater than 120 mg should be administered in divided doses.

At least 75 % of an oral dose reaches the systemic circulation as the active metabolite.

PHARMACEUTICAL FORM AND CONTENTS ol Solution for injection - Pack of 10 doses:

The vaccine is a powder for suspension for injection contained in a 10 doses vial.

The recommended starting dose is 4 mg daily, given as a single dose, or in two 2 mg doses.

Less than 2 % of an ocular dose of travoprost was recovered in urine as free acid.

This may be administered as either 150 mg (15 ml) twice daily or 300 mg (30 ml) once daily (see section 4.4).

Only about 20-30 % of a given dose of degarelix is excreted unchanged by the kidneys.

Approximately 38 % of an intravenous dose is excreted in the urine as unchanged substance.

Most (about 87 %) of the administered dose is excreted in the urine as MPAG.

The main part of the dose is excreted in faeces as metabolites and unchanged drug.

Valsartan is primarily eliminated in faeces (about 83 % of dose) and urine (about 13 % of dose), mainly as unchanged drug.

Excretion After intravenous administration, 25 % of the dose was excreted as metabolites within 24 hours.

Approximately 60-70 % of the dose was recovered in the urine as active substance.

Less than 1 % of the therapeutic dose of amprenavir is excreted unchanged in the urine.

Trizivir was shown to be bioequivalent to abacavir 300 mg, lamivudine 150 mg and zidovudine 300 mg given as separate tablets for AUC0-∞ and Cmax.