These diseases are transmissible to experimental animals by inoculation or by ingestion in food.

Greater number of tumor cures and smaller number of sc tumors in the site of tumor transplantation in treated groups of ipEAT was found.

Recalling that the aim of the Council of Europe is to achieve a greater unity between its members and that it wishes to co operate with other States in the protection of live animals used for experimental and other scientific purposes;

Recalling that the aim of the Council of Europe is to achieve a greater unity between its members and that it wishes to co-operate with other States in the protection of live animals used for experimental and other scientific purposes;

experiment on animals

The requirements laid down in Table 2 must be fulfilled by any laboratory where animal experiments with classical swine fever virus are carried out.

(9) Animal protection requires that the number of experiments conducted on animals be restricted.

The substance to be tested is applied in a single dose to one of the eyes in each of several experimental animals;

chemical products, including validation of alternative non-animal testing procedures;

any information which, if withheld, might lead to animal experiments being carried out or repeated needlessly,

Where experiments are essential, it must be checked whether tests on animals cannot be replaced or limited by using other methods.

The substance to be tested is applied in a single dose to the skin of several experimental animals, each animal serving as its own control.

The test substance is applied to the skin in graduated doses to several groups of experimental animals, one dose being used per group.

The test substance is applied daily to the skin in graduated doses to several groups of experimental animals, one dose per group, for a period of 28 days.

Although a variety of experimental animals have been used it is recommended that testing be performed using healthy adult albino rabbits.

The test substance is administered orally, daily, in graduated doses to several groups of experimental animals, one dose per group for a period of 28 days.

The test substance is administered orally by gavage in graduated doses to several groups of experimental animals, one dose being used per group.

Several groups of experimental animals are exposed for a defined period to the test substance in graduated concentrations, one concentration being used per group.

Several groups of experimental animals are exposed daily for a defined period to the test substance in graduated concentrations, one concentration being used per group, for a period of 28 days.

Commission Directive 2000/41/EC of 19 June 2000 postponing for a second time the date after which animal tests are prohibited for ingredients or combinations of ingredients of cosmetic products (Text with EEA relevance)

details concerning test animals which may be at increased risk owing to their age, their mode of rearing or feeding, or the purpose for which they are intended, or animals the physiological or pathological condition of which requires special consideration;

technological platforms for the developments in the fields of new diagnostic, prevention and therapeutic tools (including pharmacogenomic approaches, stem cell research and alternative methods to animal testing).

Pharmacological studies are of fundamental importance in clarifying the mechanisms by which the medicinal product produces its therapeutic effects and therefore pharmacological studies conducted in experimental and target species of animal should be included in Part 4.

In the second case, where scientific justification for the combination is sought through therapeutic experimentation, the investigation shall determine whether the effects expected from the combination can be demonstrated in animals, and the importance of any collateral effects shall at least be investigated.

(10) Member States shall also ensure that all tests on animals are conducted in accordance with Council Directive 86/609/EEC of 24 November 1986 on the approximation of laws, regulation and administrative provisions of the Member States regarding the protection of animals for experimental and other scientific purposes.

Member States ensure that all experiments on animals are conducted in accordance with Council Directive 86/609/EEC of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes (1).

Whereas the aim of the Directive is to ensure that where animals are used for experimental or other scientific purposes the laws, regulations and administrative provisions in the Member States for their protection are harmonized so as to avoid affecting the establishment and functioning of the common market, in particular by distortions of competition or barriers to trade;

In order to provide information on the costs entailed in applying for review and on the need for animal testing for the purposes of compiling the complete dossier, participants may submit to the Rapporteur Member State together with the complete dossiers a breakdown of the costs of the respective actions and studies carried out.

The Commission shall include in the report referred to in Article 18(5) of Directive 98/8/EC information on the costs entailed in compiling the complete dossier and on the animal testing carried out for that purpose, together with any appropriate recommendations concerning modifications of data requirements in order to reduce to a minimum the need for testing on vertebrate animals, and to ensure cost-effectiveness and proportionality.

A series of mouse bioassay procedures, differing in the test portion (hepatopancreas or whole body) and in the solvents used for the extraction and purification steps, can be used for detection of the toxins mentioned in Article 1. Sensitivity and selectivity depend on the choice of the solvents used for the extraction and purification steps and this should be taken into account when making a decision on the method to be used, in order to cover the full range of toxins.

Council Directive 86/609/EEC(5) of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes(6) provides that an animal test shall not be carried out if an alternative method is available.

Animal protection requires that the number of experiments conducted on animals be restricted.

development of new in vitro tests to replace animal experimentation;

Animal experiments did not reveal impairment of fertility by lamotrigine.

Tetranor-iloprost is pharmacologically inactive as shown in animal experiments.

Studies in animals have shown reproductive toxicity (see sections 5.1 and 5.3).

Experiments on animals taken from the wild may not be carried out unless experiments on other animals would not suffice for the aims of the experiment.

whereas all appropriate measures should be taken to avoid the duplication of tests on animals;

Animal models have shown that nitric oxide may interact with haemostasis, resulting in an increased bleeding time.

Fertility Animal experiments did not reveal impairment of fertility by lamotrigine (see section 5.3).

Animal experiments have shown that ciprofloxacin passes the placenta and is excreted in breast milk.

In experimental animals, it has been shown that P-gp is a major determinant of Enviage bioavailability.

In experimental animals, it has been shown that P-gp is a major determinant of Rasilez bioavailability.

In experimental animals, it has been shown that P-gp is a major determinant of Riprazo bioavailability.

In experimental animals, it has been shown that P-gp is a major determinant of Sprimeo bioavailability.

In experimental animals, it has been shown that P-gp is a major determinant of Tekturna bioavailability.

That report shall contain precise data on the number and type of experiments relating to cosmetic products carried out on animals.

This particularly applies (pursuant to Directive 86/609/EEC) to animal experiments involving species which are closest to human beings.

The report shall contain precise data on the number and type of experiments relating to cosmetic products carried out on animals.

Animal studies have shown that pramipexole inhibits dopamine synthesis, release, and turnover.