trimethoprim

Trimethoprim

Trimethoprim and sulfamethoxazole.

Trimethoprim 66,7 mg Sulfadiazine 333,3 mg

Trimethoprim 58 mg/ g Sulfadiazine 288,3 mg/ g

Trimethoprim 5.78%w/ w Sulfadiazine 28.89 % w/ w

Trimethoprim 5 mg

Trimethoprim is a diaminopyrimidine, a synthetic folic acid antagonist.

Treatment should be continued until 2 days after symptoms have resolved, up to a maximum of 5 days.

Trimethoprim-sulfamethoxazole

The drug is contraindicated for women who are pregnant.

Adverse reactions associated with the use of trimethoprim-sulfamethoxazole in patients without HIV infection are rare.

The antimicrobial combination of trimethoprim and sulfamethoxazole is active in vitro against varius gram-positive and gram-negative bacteria.

Whereas, in order to allow for the completion of scientific studies in progress, the duration of the validity of the provisional maximum residue limits previously defined in Annex III to Regulation (EEC) No 2377/90 should be extended for trimethoprim;

Sulfadiazine 333 mg Trimethoprim 67 mg

Sulfadiazine 333 mg/ g Trimethoprim 67 mg/ g

Pro 100 g: Trimethoprim 6,66 g Sulfadiazine 33,34 g

Each gram contains: Sulfadiazine 333 mg Trimethoprim 67 mg

Trimethoprim or Tetroxoprim solution (see 5.1.3) (1) 10 ml

1 g contains: Trimethoprim 58,00 mg, sulfadiazine 288,30 mg

- inhibitors of dihydrofolate reductase (e. g. methotrexate, trimethoprim)

Trimethoprim 20 mg/ ml Sulfamethoxazole 100 mg/ ml N-Methyl-2-

Active substances per gram: Trimethoprim 66,7 mg Sulfadiazine 333,3 mg

Add trimethoprim or tetroxoprim and sterilize at 121 p 1 oC for 15 minutes;

5-12 mg trimethoprim and 25-58 mg sulfamethoxasole per kg body weight per day for 3-5 days

Preparation Dissolve the trimethoprim or tetroxoprim in ethanol (5 or 30 ml) and dilute with water.

Sulfamethoxazole/Trimethoprim2

Infections in horses caused by micro-organisms sensitive to trimethoprim + sulphonamide

Trimethoprim/ sulfamethoxazole: no effect on the bioavailability of MPA was observed.

Antibiotics Sulphamethoxazole/ Trimethoprim 800 mg/ 160 mg BID (Indinavir 400 mg QID) Antifungals

Whereas danofloxacin, cefazolin and trimethoprim should be inserted into Annex I to Regulation (EEC) No 2377/90;

The Cmax of trimethoprim is 0.29 µg/ g.

Dose alteration of sulfamethoxazole/trimethoprim during concomitant ritonavir therapy should not be necessary.

Within 48 hours after the last medication trimethoprim, sulfamethoxazole and their metabolites are undetectable in urine and faeces.

Trimethoprim or Tetroxoprim solution

Plasma elimination half-life for trimethoprim in poultry is less than 1 hour and that of sulfamethoxazole, approximately 1.5 hours.

In case of allergy to trimethoprim or sulfonamides, special care should be taken when handling this product or the medicated solution.

OPINION FOLLOWING AN ARTICLE 35 REFERRAL FOR VETERINARY MEDICINAL PRODUCTS WHICH CONTAIN THE ACTIVE SUBSTANCES TRIMETHOPRIM AND SULFADIAZINE

A synergistic and bactericidal effect occurs when trimethoprim is combined with sulfamethoxazole, because trimethoprim and sulfamethoxazole inhibit sequential steps in the synthesis of tetrahydrofolic acid, an essential metabolic cofactor in bacterial synthesis of purine and, subsequently, DNA.

In vitro trimethoprim is generally bacteriostatic and has a broad spectrum of activity against both gram- positive and gram-negative bacteria.

Treatment and prevention of respiratory infections caused by Escherichia coli susceptible to trimethoprim and sulfamethoxazole where the disease has been diagnosed in the flock.

Although concomitant administration of inhibitors of dihydrofolate reductase (e. g. methotrexate, trimethoprim) has not been studied, such medicinal products may interfere with BH4 metabolism.

Based on the identical composition with respect to active ingredients, Trimethoprim and Sulfadiazine, the same pharmaceutical form, and proven bioequivalence between Equibactin vet. Oral Paste and Tribrissen oral paste for trimethoprim as well as for sulfadiazine, the products are regarded to be essentially similar.

Infections in horses caused by micro-organisms sensitive to trimetoprim + sulphonamide, e. g. infections in the airways, GI-

Administration of trimethoprim/ sulfamethoxazole 160 mg/ 800 mg results in a 40 % increase in lamivudine exposure, because of the trimethoprim component; the sulfamethoxazole component does not interact.

Treatment and prevention of respiratory infections caused by Actinobacillus pleuropneumoniae susceptible to trimethoprim and sulfamethoxazole where the disease has been diagnosed in the herd.

25 mg sulfadiazine and 5 mg trimethoprim per kg BW per day, during max.

Sulfamethoxazole was co-administered with trimethoprim.

333.3 mg/ g sulfadiazine and 66.7 mg/ g trimethoprim.

Administration of trimethoprim/ sulfamethoxazole 160 mg/ 800 mg results in a 40 % increase in lamivudine exposure, because of the trimethoprim component.