TRITON was a 13,608 patient, multicentre international, randomised, double blind, parallel group study.

However, the requirement for three-point belts in all seating positions in M1 vehicles shall apply with effect from 1 October 2004.

However, the requirement for three-point belts in all seating positions in M1 vehicles shall apply with effect from 1 April 2002.

In the light of technical progress it is possible to improve the protection provided for passengers by requiring the installation of three-point belts with retractors for all seats of motor vehicles of category M1.

tritoqualine

Tritolyl phosphite

On three point belts fitted with retractors, one retractor must operate at least on the diagonal strap.

in the case of tractors equipped for the fitting of portable devices at the front, two dipped-beam headlamps in addition to the lamps mentioned in 4.2.4.2.1 shall be allowed at a height not exceeding 2 800 mm if:

Whereas the adoption of a Directive on the mandatory wearing of safety belts for all occupants of vehicles of less then 3,5 tonnes should be linked to a further modification of the Directive aiming to render mandatory the installation of three-point belts with retractors also for the rear outboard seats of such vehicles;

in the case of tractors equipped for the fitting of portable devices at the front, two dipped-beam headlamps in addition to the lamps mentioned in 4.2.4.2.1 shall be allowed at a height not exceeding 3 000 mm, if the electrical connections are such that two pairs of dipped-beam headlamps cannot be switched on at the same time.';

Commission Decision of 8 April 2002 recognising in principle the completeness of the dossiers submitted for detailed examination in view of the possible inclusion of nicobifen, tritosulfuron and bifenazate in Annex I to Council Directive 91/414/EEC concerning the placing of plant-protection products on the market (Text with EEA relevance) (notified under document number C(2002) 1306)

Patients with Outcome Events in TRITON Primary Analysis

Efient was administered without regard to food in TRITON.

""A" for a three-point belt,

Polyethyleneglycol-mono-p(1,1,3,3-tetramethylbutyl)-phenyl-ether (e.g. Triton X-100), 1 % by volume 10 ml

Polyethyleneglycol-mono-p-(1,1,3,3-tetramethylbutyl)-phenyl-ether (e.g. Triton x-100), 1 % by volume 10 ml

The use of oral anticoagulants, non-study antiplatelet medicinal products and chronic NSAIDs was not allowed in TRITON.

Hydraulic lifting gear, three-point linkage

Adverse Reactions Table 2 summarises haemorrhagic and non-haemorrhagic adverse reactions in TRITON classified by frequency and system organ class.

Hydraulic lift - three-point coupling:

Hydraulic lift: three-point coupling: yes/no (1)

No toxicological effects due to the solvent detergent reagents (TnBP and Triton X-100) used in the virus inactivation procedure are expected since the residual levels are less than 5 µg/ ml.

Efficacy and Safety in Acute Coronary Syndrome (ACS) The phase 3 TRITON study compared Efient (prasugrel) with clopidogrel, both co-administered with ASA and other standard therapy.

(hook or special threepoint linkage system)

Non-Coronary Artery Bypass Graft (CABG) related bleeding In TRITON, the frequency of patients experiencing a non-CABG related bleeding event is shown in Table 1.

In TRITON, for every 1000 patients treated with Efient, there were 22 fewer patients with myocardial infarction, and 5 more with non– CABG-related TIMI major haemorrhages, compared with patients treated with clopidogrel.

Studies performed in bacteria to determine mutagenicity were negative for Thrombin alone, Biological Active Component (containing fibrinogen, citrate, glycine, tranexamic acid, and arginine hydrochloride), TnBP alone, and Triton X-100 alone at all concentrations tested.

"three-point belt" means a belt which is essentially a combination of a lap strap and a diagonal strap;

Maximum vertical load at the coupling point (hook or special threepoint coupling system)

Test in configuration of a three-point belt without retractor or with a retractor at the upper belt anchorage.

Safety in patients with acute coronary syndrome undergoing PCI was evaluated in one clopidogrel- controlled study (TRITON) in which 6741 patients were treated with prasugrel (60 mg loading dose and 10 mg once daily maintenance dose) for a median of 14.5 months (5802 patients were treated for over 6 months, 4136 patients were treated for more than 1 year).

, three-point belts of a type specified in Annex XV shall be provided unless one of the following conditions is fulfilled:

At rear seating positions of vehicles in category M1, lap-belts or three-point belts, whether or not fitted with retractors."

D= concentration in μmol/ml (= 2,50) of concentrated tryptophan solution (3.15) added to calibration solution (3.17)

THE LETTER " A " IN THE CASE OF A THREE-POINT BELT , THE LETTER " B " IN THE CASE OF A LAP BELT AND THE LETTER " S " IN THE CASE OF A SPECIAL TYPE BELT.

For tritosulfuron an application was submitted by BASF AG, Germany, to the authorities of Germany on 8 June 2001.

Test in configuration of a three-point belt incorporating a retractor having a pulley or strap guide at the upper belt anchorage

"3.1.1. for the front outboard seating positions, three-point safety belts with emergency locking retractors having multiple sensitivity (1.8.4);

" THREE-POINT BELT " MEANS ANY BELT ASSEMBLY WHICH IS ANCHORED AT THREE POINTS AND IS A COMBINATION OF A LAP BELT AND A DIAGONAL BELT;

in the case of three-point belts, a tension of at least 50 N can be established in the lap section of the belt by external application of tension in the diagonal section of the belt.`,

675 daN ± 20 daN in the horizontal plane of the vehicle and towards the front of the vehicle on the lap portion of the belt and 675 daN ± 20 daN in the horizontal plane of the vehicle and towards the front of the vehicle on the torso portion of the belt in the case of 3-point belt;

two lower anchorages and one upper anchorage which allow the installation of a three point safety belt type A or, where required by Annex XV of Directive 77/541/EEC, type Ar, Ar4m or Ar4Nm.

All concentrations of the combination of TnBP and Triton X-100 also tested negative in assays performed to determine mammalian cell mutageneicity, chromosomal aberrations and micronuclei induction.

sulphinpyrazone, certain long acting sulphonamides, tetracyclines, MAO-inhibitors, quinolone antibiotics, probenecid, miconazol, pentoxifylline (high dose parenteral), tritoqualine, fluconazole.

Whereas in the light of technical progress it is possible to improve the protection provided for passengers by requiring the installation of three-point belts with retractors for the rear outboard seats of motor vehicles of category M1;

675 daN ± 20 daN in an angle of 45 ° ± 10 ° to the horizontal plane of the vehicle and towards the front of the vehicle on the lap portion of the belt and 675 daN ± 20 daN in the horizontal plane of the vehicle and towards the front of the vehicle on the torso portion of the belt in the case of 3-point belt;

The belt anchorages shall be submitted to the test prescribed in point 5.4.1 in which the loads are transmitted to them by means of a device reproducing the geometry of a three-point safety belt equipped with a retractor having a pulley or strap guide at the upper belt anchorage.

EACH MEMBER STATE SHALL GRANT EEC COMPONENT TYPE-APPROVAL FOR ANY TYPE OF THREE-POINT OR LAP SAFETY BELT AND ANY TYPE OF RESTRAINT SYSTEM WHICH SATISFIES THE DESIGN AND TEST REQUIREMENTS LAID DOWN IN 2 OF ANNEX I AND IN ANNEXES IV TO XIV.

Commission Decision of 8 April 2002 recognising in principle the completeness of the dossiers submitted for detailed examination in view of the possible inclusion of nicobifen, tritosulfuron and bifenazate in Annex I to Council Directive 91/414/EEC concerning the placing of plant-protection products on the market

If the buckle or adjusting device is part of the attachment or of the common component of a three-point strap, the buckle or adjusting device must be tested together with the attachment in accordance with Item 2.7.6.2, except in the case of retractors with a return pulley at the upper strap anchorage.