Kadar je treba opraviti postopek, se skrbno preuči izbor vrste in se, kjer je treba, pojasni pristojnemu organu; pri izbiri postopkov je treba izbrati tiste, ki uporabljajo minimalno število živali, povzročijo najmanj bolečine, trpljenja, stiske ali trajne škode in bodo najverjetneje dali zadovoljive rezultate.
When a procedure has to be performed, the choice of species shall be carefully considered and, where required, be explained to the responsible authority; in a choice between procedures, those should be selected which use the minimum number of animals, cause the least pain, suffering, distress or lasting harm and which are most likely to provide satisfactory results.