Useful information may also be available from the observations carried out in efficacy testing.

However, observation over longer treatment periods is required before any effect of natalizumab on malignancies can be excluded.

Whereas, in the case of all category N3 vehicles (rigid lorries with or without trailer and articulated tractors), existing provisions have proved inadequate as regards the field of vision in the area adjacent to the side of the cab structure opposite the driver and whereas, in order to remedy this shortcoming, it has proved necessary to require the fitting of a 'close-proximity' rear-view mirror;

each observation made on each animal including grading system if one is used;

Member States shall set up a monitoring programme for the purpose of verifying compliance with this Directive.

Complete haematological response (CHR) in CP patients was evaluated as a secondary endpoint.

Whereas it is appropriate to regulate the observer scheme by means of one Regulation and therefore repeal Regulation (EEC) No 3928/92;

Whereas the NAFO Fisheries Commission adopted a recommendation on 13 September 1996 to amend the observer scheme;

Based on observations with other alpha and beta interferons, an increased risk of abortions cannot be excluded.

Behavioral observations should be made by a trained person, particularly in reference to the knowledge of the ethology of the species.

At each observation each bird is recorded normal (O), sick (1), severely sick (2) or dead (3).

Whereas on 15 September 1995, the NAFO Fisheries Commission adopted a proposal to introduce a global observer scheme;

Attention should be directed to observations of tremors, convulsions, salivation, diarrhoea, lethargy, sleep and coma.

The effectiveness was measured by looking at the level of iron contained in the liver before and after one year of treatment with the medicines.

The results of these showed no unanticipated or systemic effects of toxicity during the observation period and after administration.

The table shall be submitted within five months of the end of the last quarterly period of observation of the relevant year.

In PIER, the primary efficacy endpoint was mean change in visual acuity at 12 months compared with baseline.

Over the 10-year observation period, the cumulative rate of varicella was 7.5 % after 1 dose and 2.2 % after 2 doses.

determination of mass in the practice of medicine for weighing patients for the purposes of monitoring, diagnosis and medical treatment;

'Apparent surface` for a defined direction of observation, means the orthogonal projection of the light-emitting surface in a plane perpendicular to the direction of observation (see drawing in Appendix 2) and tangential to the most exterior point of the lens.

The reference week and the date of the interview may not be more than five weeks apart, except in the third quarter,

Change in stocks (positive or negative) is the difference between the value of the stocks at the end and the beginning of the reference period.

It is necessary to specify the first reference year for the compilation of the results laid down in Article 3 of Regulation (EC, Euratom) No 2056/2002.

The primary efficacy parameter was the same as in TAP (see above), with an additional endpoint of month 24 defined.

The transmission of provisional monthly and quarterly data shall take place within three months of the end of the corresponding reference period,

For patients randomized to the maintenance phase of the trial, the median observation time was 28 months from maintenance randomisation.

At the end of the observation period and before leaving the vessel the observer shall draw up a report in accordance with the model in Appendix 2 to this Annex.

the variable '1.5 the existence of collective pay agreements covering the majority of employees in the observed unit' shall be optional;

When possible and for each observation time, the LC50 and the confidence limits (p = 0,05) should be estimated using standard procedures;

When possible and for each observation time, the EC50 and the confidence limits (p = 0,05) should be estimated using standard procedures;

Services paid for during the reference period are also included regardless of whether they are industrial or non-industrial.

NEAFC inspectors shall carry out surveillance based on sightings of fishing vessels from a vessel or aircraft assigned to the Scheme.

By way of derogation from the first subparagraph, Member States may allow premixtures to be incorporated in compound feedingstuffs in a proportion as low as 0,05 % by weight, provided that the quantitative and qualitative composition of the premixture so permits and that they have first established that the establishments satisfy the conditions set out in Chapter I.2 (b) of the Annex, with a view to achieving homogeneous distribution of premixtures and observing the additive levels set for the whole feedingstuff.

Whereas the European Size Unit constitutes a basic unit expressed in terms of monetary value for a given reference period;

If measurements are taken closer to the lamp, there must be a parallel shift in the direction of observation to achieve the same accuracy.

where not laid down by this Regulation, the reference period applicable to each category of statistics relating to the trading of goods between Member States,

implementation of new inspection and observer schedules in the framework of Regional Fishery Organisations (RFOs) to which the Community is a contracting party;

On the other hand, the ancillary activities of the observation unit are not separated from the principal or secondary activities they serve.

This variable is defined as the change in stocks at purchaser's prices exclusive of VAT between the end and the beginning of the reference period.

Within twelve weeks of the end of the reference period in the case of a continuous survey (and within nine months of the end of the reference period in the case of a survey in the spring), the Member States shall forward to Eurostat the results of the survey, without direct identifiers.

Some of the technical measures adopted by the CCAMLR have been transposed by Council Regulation (EEC) No 3943/90 of 19 December 1990 on the application of the system of observation and inspection established under Article XXIV of the Convention on the Conservation of Antarctic Marine Living Resources(3), and by Council Regulation (EC) No 66/98 of 18 December 1997 laying down certain conservation and control measures applicable to fishing activities in the Antarctic(4).

Special attention shall be given to observe and document changes in the applied methods of the inventory, transport and analysis.

a comparison of model calculations with observations of acidification, eutrophication and ground-level ozone with a view to improving models;

The first reference year for which statistics on characteristics 21 12 0 and 21 14 0 are to be compiled is the calendar year 2001.

The mean, the total number of observations (before and after imputation) and the standard errors for the following income components:

Following cladribine, the incidence of second malignancies ranges from 0 % to 9.5 % after a median observation period of 2.8 to 8.5 years.

The weight of the offspring in the treated group was noted to be less than that of the control group during the observation period.

Secondary endpoints included histological response, ALT normalisation, and various measures of antiviral efficacy.

Induction phase: overview of efficacy results for CHOP vs. R-CHOP (31 months median observation time)

the definitions of the characteristics and their relevance for certain activities (Article 4); (iv) the definition of the reference period (Article 4);